Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 14/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26628352 | 0.82 | SLC6A2 (0.43) | MPOSLC6A4HTR2AHTR2CSLC6A2 | |
| SCHEMBL9486710 | 0.76 | SLC6A2 (0.42) | MPOSLC6A4HTR2AHTR2CSLC6A2 | |
| SCHEMBL434483 | 0.71 | IDO1 (0.46) | SLC6A4HTR2AHTR2CSLC6A2SLC6A3 | |
| SCHEMBL24460394 | 0.69 | SLC6A4 (0.33) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL20356017 | 0.69 | CA3 (0.48) | MPOHTR2A | |
| SCHEMBL14668128 | 0.67 | TAAR1 (0.52) | MPOSLC6A4HTR2CSLC6A2SLC6A3 | |
| SCHEMBL6983001 | 0.66 | AOC3 (0.48) | — | |
| SCHEMBL14131195 | 0.66 | TYR (0.53) | — | |
| SCHEMBL23259114 | 0.66 | NR3C2 (0.39) | MPOSLC6A4HTR2CSLC6A2SLC6A3 | |
| SCHEMBL9076233 | 0.66 | IDO1 (0.41) | MPOSLC6A4HTR2AHTR2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901474-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044326-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-27 | — | — | WO | disclosed |