Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.38 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL8324934 | 1.00 | HTR2A (0.43) | HTR2AHTR2CCHRNA4CHRNB2CHRNB4 | |
| Formic Acid SCHEMBL8324932 | 1.00 | HTR2A (0.43) | HTR2AHTR2CCHRNA4CHRNB2CHRNB4 | |
| SCHEMBL8328024 | 0.92 | HTR2A (0.46) | HTR2AHTR2CCHRNA4CHRNB2CHRNB4 | |
| SCHEMBL8328027 | 0.92 | HTR2A (0.46) | HTR2AHTR2CCHRNA4CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL8327629 | 0.90 | HTR2A (0.45) | HTR2AHTR2CCHRNA4CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL8327632 | 0.90 | HTR2A (0.45) | HTR2AHTR2CCHRNA4CHRNB2CHRNB4 | |
| Hydrochloric Acid SCHEMBL8327635 | 0.90 | HTR2A (0.45) | HTR2AHTR2CCHRNA4CHRNB2CHRNB4 | |
| SCHEMBL18229903 | 0.69 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1NOTUM | |
| SCHEMBL18229914 | 0.69 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1NOTUM | |
| SCHEMBL18229904 | 0.69 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |