Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR2C | P28335 | 5/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328027 | 1.00 | HTR2A (0.46) | HTR2AHTR2CBPTFCHRNA7CHRNB2 | |
| Hydrochloric Acid SCHEMBL8327629 | 0.98 | HTR2A (0.45) | HTR2AHTR2CBPTFCHRNA7CHRNB2 | |
| Hydrochloric Acid SCHEMBL8327632 | 0.98 | HTR2A (0.45) | HTR2AHTR2CBPTFCHRNA7CHRNB2 | |
| Hydrochloric Acid SCHEMBL8327635 | 0.98 | HTR2A (0.45) | HTR2AHTR2CBPTFCHRNA7CHRNB2 | |
| Formic Acid SCHEMBL8324928 | 0.92 | HTR2A (0.43) | HTR2AHTR2CBPTFCHRNA7CHRNB2 | |
| Formic Acid SCHEMBL8324934 | 0.92 | HTR2A (0.43) | HTR2AHTR2CBPTFCHRNA7CHRNB2 | |
| Formic Acid SCHEMBL8324932 | 0.92 | HTR2A (0.43) | HTR2AHTR2CBPTFCHRNA7CHRNB2 | |
| SCHEMBL8321466 | 0.74 | CYP2D6 (0.41) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL8321461 | 0.74 | CYP2D6 (0.41) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL18911725 | 0.73 | HTR2A (0.46) | HTR2AHTR2CNOTUMSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |