Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.49 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322805 | 0.84 | BRS3 (0.48) | NR1H4BRS3CCR5HDAC8HDAC6 | |
| SCHEMBL8321377 | 0.82 | BRS3 (0.41) | NR1H4BRS3CCR5HDAC8HDAC6 | |
| SCHEMBL8324028 | 0.80 | NR1H4 (0.40) | NR1H4BRS3KDM1AHDAC8HDAC6 | |
| SCHEMBL8325359 | 0.76 | CA12 (0.43) | NR1H4 | |
| SCHEMBL8319084 | 0.73 | TAAR1 (0.43) | NR1H4KDM1AHDAC8HDAC6 | |
| SCHEMBL8323886 | 0.73 | NR1H4 (0.40) | NR1H4BRS3HDAC8HDAC6 | |
| SCHEMBL8324344 | 0.73 | HDAC8 (0.41) | NR1H4KDM1AHDAC8HDAC6 | |
| SCHEMBL8325041 | 0.69 | HDAC3 (0.42) | NR1H4DGAT1HDAC8HDAC6 | |
| SCHEMBL8325020 | 0.69 | NR1H4 (0.45) | NR1H4HDAC8HDAC6 | |
| SCHEMBL19717163 | 0.69 | HDAC8 (0.51) | NR1H4KDM1AHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |