SCHEMBL8325236

SCHEMBL8325236

CSc1c(C)cccc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.57
KDM4E B2RXH2 3/20 0.57
HPGD P15428 2/20 0.57
HSD17B10 Q99714 2/20 0.57
MYC P01106 1/20 0.52
CYP3A4 P08684 2/20 0.49
CYP2C9 P11712 2/20 0.49
KMT2A Q03164 2/20 0.49
POLB P06746 3/20 0.47
MEN1 O00255 1/20 0.46
AKR1B10 O60218 1/20 0.46
TRPA1 O75762 1/20 0.46
ABCB11 O95342 1/20 0.46
DHFR P00374 1/20 0.46
LMNA P02545 1/20 0.46
MPO P05164 1/20 0.46
CYP1A2 P05177 1/20 0.46
CHRM1 P11229 1/20 0.46
AKR1B1 P15121 1/20 0.46
PTGS1 P23219 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14240305 0.87 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL6224766 0.86 ALDH1A1 (0.59) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL1559662 0.82 PARP1 (0.46) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL27388138 0.82 ALDH1A1 (0.41) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL11755514 0.82 AKR1C3 (0.48) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL7280214 0.81 CA12 (0.55) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL8175044 0.80 ALDH1A1 (0.38) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL7364595 0.79 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL19847390 0.79 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDHSD17B10MYC
SCHEMBL27721378 0.79 NR4A2 (0.47) ALDH1A1KDM4EHPGDHSD17B10MYC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105646356-A Preparation method of sulfophenyl pyrazolone and intermediate thereof 浙江省诸暨合力化学对外贸易有限公司 2016-06-08 CN disclosed
CN-102924352-B Method for synthesizing 4-mercaptobenzoate BEIJING INSIGHT HIGH TECHNOLOGY CO LTD 2013-11-20 CN disclosed
CN-102924352-A Method for synthesizing 4-mercaptobenzoate BEIJING INSIGHT HIGH TECHNOLOGY CO LTD 2013-02-13 CN disclosed
EP-0858444-A4 CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO INC (US) 1999-12-01 EP disclosed
EP-0858444-A1 CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-08-19 EP disclosed
US-5750549-A ANTIINFLAMMATORY AGENTS OR ANALGESICS MERCK & CO., INC. (US) 1998-05-12 US disclosed
WO-1997014671-A1 CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1997-04-24 WO disclosed
CN-1070400-A Benzoglyoxaline FISONS PLC (GB) 1993-03-31 CN disclosed