Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325041 | 0.89 | HDAC3 (0.42) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8325932 | 0.86 | HDAC1 (0.44) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8325738 | 0.83 | HPGDS (0.43) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8325026 | 0.76 | HDAC3 (0.48) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8322585 | 0.75 | HDAC1 (0.43) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8318738 | 0.75 | HDAC1 (0.49) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL27645996 | 0.73 | NR1H4 (0.48) | NR1H4AKR1B10AKR1B1MEN1KMT2A | |
| SCHEMBL6732593 | 0.73 | NR1H4 (0.50) | HDAC8HDAC2NR1H4AKR1B10AKR1B1 | |
| SCHEMBL6732590 | 0.73 | NR1H4 (0.50) | HDAC8HDAC2NR1H4AKR1B10AKR1B1 | |
| SCHEMBL4679570 | 0.72 | NR1H4 (0.50) | NR1H4AKR1B10AKR1B1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |