SCHEMBL8325369

SCHEMBL8325369

NCC/C=C/c1cc(Cl)cc(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.45
IDO1 P14902 2/20 0.35
TSHR P16473 1/20 0.35
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
GRIN1 Q05586 1/20 0.30
GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1569554 0.80 CHAT (0.50) GRIN1GRIN2B
SCHEMBL1569784 0.80 CHAT (0.50) GRIN1GRIN2B
SCHEMBL1569551 0.80 CHAT (0.50) GRIN1GRIN2B
SCHEMBL5682382 0.78 AHR (0.45) AHR
SCHEMBL5547835 0.78 AHR (0.45) AHRIDO1TSHRCA12CA1
SCHEMBL5547833 0.78 AHR (0.45) AHRIDO1TSHRCA12CA1
SCHEMBL5682380 0.78 AHR (0.45) AHR
SCHEMBL8325205 0.78 AHR (0.45) AHR
SCHEMBL28015714 0.78 AHR (0.45) AHRTSHR
SCHEMBL5542151 0.75 AHR (0.42) AHRTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004071445-A2 2-(AMINOMETHYL)ARYLAMIDE ANALGESICS PHARMACOPEIA DRUG DISCOVERY, INC. (US) 2004-08-26 WO disclosed