Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320556 | 0.87 | HDAC1 (0.51) | MAPTHTTTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8325932 | 0.81 | HDAC1 (0.44) | MAPTHTTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8325041 | 0.80 | HDAC3 (0.42) | MAPTHTTALDH1A1SMN1; SMN2HDAC2 | |
| SCHEMBL8319497 | 0.78 | MAPT (0.40) | MAPTALDH1A1SMN1; SMN2KDM4EHDAC2 | |
| SCHEMBL8323566 | 0.77 | MAPT (0.35) | MAPTHTTTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8324344 | 0.76 | HDAC8 (0.41) | HTTHDAC2HDAC3HDAC4HDAC1 | |
| SCHEMBL8320578 | 0.76 | MAPT (0.47) | MAPTTDP1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8324376 | 0.76 | RNASEH1 (0.47) | MAPTHTTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7695878 | 0.73 | CYP1A2 (0.56) | MAPTHTTALDH1A1SMN1; SMN2HDAC2 | |
| SCHEMBL804964 | 0.73 | CYP1A2 (0.56) | MAPTHTTALDH1A1SMN1; SMN2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |