Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 3/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.38 |
| ▸ | GART | P22102 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9556348 | 1.00 | L3MBTL1 (0.52) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL27814132 | 1.00 | L3MBTL1 (0.52) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9555960 | 0.92 | L3MBTL1 (0.51) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9555966 | 0.92 | L3MBTL1 (0.51) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9556169 | 0.88 | L3MBTL1 (0.47) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9556165 | 0.88 | L3MBTL1 (0.47) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL8321601 | 0.85 | L3MBTL1 (0.55) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL27319312 | 0.85 | L3MBTL1 (0.55) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL6655031 | 0.85 | L3MBTL1 (0.55) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL2315180 | 0.84 | L3MBTL1 (0.53) | L3MBTL1KMT2APOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106957296-B | 5- ((alkoxymethylene) amino) thienyl-2-formyl) -L-glutamic acid dialkyl ester and preparation method thereof | 南京正大天晴制药有限公司 | 2022-03-08 | — | — | CN | disclosed |
| CN-105111197-B | Synthesis method of raltitrexed | 上海鼎雅药物化学科技有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-106957311-B | Solvate of raltitrexed and preparation method thereof | 南京正大天晴制药有限公司 | 2020-03-31 | — | — | CN | disclosed |
| EP-0638079-B1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | STANFORD RES INST INT (US) | 1999-12-15 | — | — | EP | disclosed |
| US-5536724-A | Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins | SRI INTERNATIONAL (US) | 1996-07-16 | — | — | US | disclosed |
| WO-1993022312-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1993-11-11 | — | — | WO | disclosed |
| US-5187167-A | Antitumor agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-16 | — | — | US | disclosed |
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | disclosed |