Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325657 | 0.89 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL8325752 | 0.89 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL8326052 | 0.88 | ACAT1 (0.48) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL6640973 | 0.87 | ACAT1 (0.52) | PDE4APDE4BPDE4CPDE4DACAT1 | |
| SCHEMBL6634085 | 0.85 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL6638660 | 0.84 | ACAT1 (0.49) | ACAT1SOAT1 | |
| SCHEMBL6636803 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL7610547 | 0.81 | EDNRB (0.49) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL8330269 | 0.80 | ACAT1 (0.57) | ACAT1SOAT1 | |
| SCHEMBL8326054 | 0.79 | ACAT1 (0.68) | PDE4APDE4BPDE4CPDE4DCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0947515-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-10-06 | — | — | EP | disclosed |
| US-5843957-A | Naphthyridine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1998-12-01 | — | — | US | disclosed |