Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17002313 | 0.77 | MAPK14 (1.00) | MAPK14CSNK1DCSNK1EMAPTIDO1 | |
| SCHEMBL13946171 | 0.74 | MAPK14 (0.54) | MAPK14LMNAMAPTKMT2ANPC1 | |
| SCHEMBL7250295 | 0.74 | MAPK14 (0.63) | MAPK14CSNK1DRAB9A | |
| SCHEMBL91416 | 0.74 | RAB9A (0.59) | MAPK14CSNK1DCSNK1ELMNAMAPT | |
| SCHEMBL25785269 | 0.72 | NPC1 (0.57) | MAPK14CSNK1DCSNK1ELMNAMAPT | |
| SCHEMBL13946114 | 0.71 | MAPK14 (0.50) | MAPK14LMNAMAPTKMT2AIDO1 | |
| SCHEMBL30049841 | 0.71 | MAPK14 (0.50) | MAPK14LMNAMAPTKMT2AIDO1 | |
| SCHEMBL18960599 | 0.70 | NPC1 (0.56) | MAPK14CSNK1DCSNK1ELMNAMAPT | |
| SCHEMBL25014415 | 0.69 | NPC1 (0.54) | MAPK14CSNK1DCSNK1ELMNAMAPT | |
| SCHEMBL4676050 | 0.68 | MAPK14 (0.49) | MAPK14ITKCSNK1DCSNK1ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |