Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PPID | Q08752 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9038659 | 0.80 | GAA (0.46) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11148453 | 0.80 | GAA (0.39) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| SCHEMBL3830166 | 0.80 | GAA (0.50) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| SCHEMBL30560019 | 0.78 | GAA (0.48) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| SCHEMBL30560018 | 0.78 | GAA (0.48) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| SCHEMBL3986908 | 0.77 | GAA (0.46) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| SCHEMBL6922121 | 0.77 | GAA (0.46) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| SCHEMBL7434819 | 0.76 | GAA (0.50) | GAAMGAMSIMGAM2SMN1; SMN2 | |
| SCHEMBL28033031 | 0.76 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL3992347 | 0.76 | GAA (0.44) | GAAMGAMSIMGAM2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789571-A4 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO INC (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0789571-A1 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Merck & Co., Inc. (US) | 1997-08-20 | — | — | EP | disclosed |