Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12643754 | 0.86 | HSD17B10 (0.65) | HSD17B10MAPTALDH1A1LMNARAB9A | |
| SCHEMBL7364475 | 0.85 | GRIN2B (0.53) | HSD17B10MAPTALDH1A1LMNARAB9A | |
| SCHEMBL31529600 | 0.82 | HSD17B10 (1.00) | HSD17B10MAPTALDH1A1LMNARAB9A | |
| SCHEMBL1218749 | 0.82 | HSD17B10 (1.00) | HSD17B10MAPTALDH1A1LMNARAB9A | |
| SCHEMBL944969 | 0.80 | MAPT (1.00) | HSD17B10MAPTALDH1A1LMNARAB9A | |
| SCHEMBL8443937 | 0.77 | PKM (0.68) | HSD17B10MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL5395748 | 0.77 | MAPT (0.83) | HSD17B10MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL711507 | 0.77 | PKM (0.71) | HSD17B10RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL31734838 | 0.77 | PKM (0.71) | HSD17B10RAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL14578158 | 0.76 | MAPT (0.81) | HSD17B10MAPTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |