Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.87 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326816 | 1.00 | PDE4D (0.87) | PDE4DPDE4APDE4BPDE4CPLAU | |
| Tolafentrine SCHEMBL159331 | 0.93 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| Tolafentrine SCHEMBL29992625 | 0.93 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| Tolafentrine SCHEMBL8326829 | 0.93 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| Tolafentrine SCHEMBL4450984 | 0.93 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7356412 | 0.92 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7356403 | 0.92 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7210124 | 0.88 | PDE4D (0.89) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7211678 | 0.88 | PDE4D (0.89) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL8330131 | 0.88 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528922-B1 | NEW SULFONYL COMPOUNDS | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-06-16 | — | — | EP | disclosed |
| US-5346904-A | BRONCHODILATOR AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-09-13 | — | — | US | disclosed |