Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.78 |
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 5/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326810 | 0.88 | PDE4D (0.87) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL8326816 | 0.88 | PDE4D (0.87) | PDE4DPDE4APDE4BPDE4CMAPT | |
| Tolafentrine SCHEMBL159331 | 0.88 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CHTR7 | |
| Tolafentrine SCHEMBL8326829 | 0.88 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CHTR7 | |
| Tolafentrine SCHEMBL4450984 | 0.88 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CHTR7 | |
| Tolafentrine SCHEMBL29992625 | 0.88 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CHTR7 | |
| SCHEMBL7356412 | 0.87 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4CUTS2R | |
| SCHEMBL7356403 | 0.87 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4CUTS2R | |
| SCHEMBL7210383 | 0.86 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4CABCB1 | |
| SCHEMBL11843109 | 0.86 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4CUTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528922-B1 | NEW SULFONYL COMPOUNDS | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-06-16 | — | — | EP | claimed |
| US-5346904-A | BRONCHODILATOR AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-09-13 | — | — | US | claimed |
| EP-0528922-B1 | NEW SULFONYL COMPOUNDS | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-06-16 | — | — | EP | disclosed |
| US-5346904-A | BRONCHODILATOR AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-09-13 | — | — | US | disclosed |