Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326838 | 1.00 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL25377761 | 1.00 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL31264062 | 1.00 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL7585285 | 0.83 | PNMT (0.61) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL14149428 | 0.82 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL15704200 | 0.82 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL172636 | 0.82 | PNMT (0.69) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL14355729 | 0.82 | PNMT (0.69) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL13453377 | 0.82 | PNMT (0.69) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL31263827 | 0.82 | PNMT (0.56) | PNMTPRCPOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968944-A | TREATING STRESS AND ANXIETY RELATED DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0764153-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995033727-A1 | SUBSTITUTED PYRAZOLES HAVING CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1995-12-14 | — | — | WO | disclosed |