Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 5/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012614 | 0.88 | PLA2G1B (0.48) | PLA2G1BMRGPRX4 | |
| SCHEMBL9081030 | 0.86 | PLA2G1B (0.50) | PLA2G1BPTGER1MRGPRX4 | |
| SCHEMBL9080274 | 0.83 | PLA2G1B (0.45) | PLA2G1BPTGER1MRGPRX4NR4A2PTPN1 | |
| SCHEMBL7013388 | 0.78 | PLA2G1B (0.48) | PLA2G1BPTGER1MRGPRX4 | |
| SCHEMBL7007210 | 0.77 | PLA2G1B (0.53) | PLA2G1BPTGER1 | |
| SCHEMBL8319422 | 0.77 | PLA2G1B (0.85) | PLA2G1B | |
| SCHEMBL9082885 | 0.72 | PLA2G1B (0.58) | PLA2G1BPTPN1PTPN6PPIA | |
| SCHEMBL7013081 | 0.70 | PLA2G1B (0.70) | PLA2G1B | |
| SCHEMBL7014844 | 0.69 | ATM (0.48) | PLA2G1BPTGER1MRGPRX4MAOB | |
| SCHEMBL8615510 | 0.69 | PLA2G1B (0.50) | PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |