Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8568043 | 0.98 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EPAX8RXFP1 | |
| Hydrochloric Acid SCHEMBL8568041 | 0.98 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EPAX8RXFP1 | |
| SCHEMBL8670121 | 0.95 | MAPT (0.49) | ALDH1A1SMN1; SMN2KDM4EPAX8RXFP1 | |
| Hydrochloric Acid SCHEMBL8330479 | 0.94 | MAPT (0.48) | ALDH1A1SMN1; SMN2KDM4EPAX8RXFP1 | |
| SCHEMBL8564456 | 0.91 | MAPT (0.48) | ALDH1A1SMN1; SMN2KDM4EPAX8RXFP1 | |
| SCHEMBL9542093 | 0.90 | PDE4B (0.47) | ALDH1A1SMN1; SMN2PAX8MAPTTP53 | |
| Hydrochloric Acid SCHEMBL8559342 | 0.90 | MAPT (0.47) | ALDH1A1SMN1; SMN2KDM4EPAX8RXFP1 | |
| SCHEMBL8559604 | 0.85 | MAPT (0.62) | SMN1; SMN2KDM4EPAX8MAPTTP53 | |
| Hydrochloric Acid SCHEMBL8561142 | 0.85 | MAPT (0.61) | SMN1; SMN2KDM4EPAX8MAPTTP53 | |
| SCHEMBL8563378 | 0.84 | PDE4B (0.59) | ALDH1A1SMN1; SMN2PAX8MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |