Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328676 | 1.00 | TAAR1 (0.41) | TAAR1MEN1KMT2AHTR2AMAOB | |
| SCHEMBL8326680 | 0.78 | ERAP1 (0.37) | TAAR1HTR2A | |
| SCHEMBL8321060 | 0.78 | ERAP1 (0.37) | TAAR1HTR2A | |
| SCHEMBL3395633 | 0.74 | ERAP1 (0.38) | TAAR1HTR2A | |
| SCHEMBL7713131 | 0.72 | TAAR1 (0.57) | TAAR1 | |
| SCHEMBL7234655 | 0.72 | TAAR1 (0.41) | TAAR1MEN1KMT2AHTR2AALDH1A1 | |
| SCHEMBL11567095 | 0.71 | CA4 (0.39) | MEN1KMT2AMAOBALDH1A1 | |
| SCHEMBL6946742 | 0.70 | MEN1 (0.43) | TAAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL1162783 | 0.70 | CYP1A2 (0.57) | TAAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL7019024 | 0.68 | LTA4H (0.52) | TAAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |