Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16196798 | 0.89 | CA14 (0.34) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL18619385 | 0.84 | CA14 (0.40) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL1859771 | 0.84 | CA14 (0.40) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL2260383 | 0.83 | NFKB1 (0.36) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL2260385 | 0.83 | NFKB1 (0.36) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL7959585 | 0.82 | TDP1 (0.42) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL13215105 | 0.82 | HDAC6 (0.36) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL24594047 | 0.80 | CA14 (0.35) | HDAC6HDAC1HDAC2CA14L3MBTL1 | |
| SCHEMBL3882477 | 0.79 | HDAC6 (0.39) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL1067066 | 0.79 | CA14 (0.38) | HDAC6HDAC1HDAC2CA14CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |