SCHEMBL8328247

SCHEMBL8328247

COc1cccc(P(=O)(Cl)Cl)c1-c1c(OC)cccc1P(=O)(Cl)Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 1/20 0.43
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
CA7 P43166 3/20 0.41
CA9 Q16790 3/20 0.41
CA12 O43570 2/20 0.41
CA14 Q9ULX7 2/20 0.41
CA4 P22748 1/20 0.41
MEN1 O00255 5/20 0.40
KMT2A Q03164 5/20 0.40
MAPT P10636 5/20 0.39
KDM4E B2RXH2 3/20 0.39
HTT P42858 3/20 0.39
MAPK1 P28482 2/20 0.39
HSP90AA1 P07900 2/20 0.39
RAB9A P51151 2/20 0.39
S1PR4 O95977 1/20 0.39
G6PD P11413 1/20 0.39
S1PR1 P21453 1/20 0.39
OPRK1 P41145 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11218407 0.83 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL30480020 0.83 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL8710136 0.77 TOP1 (0.41) TOP1CA1CA2CA7CA9
SCHEMBL9177920 0.77 MEN1 (0.41) TOP1CA1CA2CA7CA9
SCHEMBL5715738 0.76 KMT2A (0.51) TOP1CA1CA2CA7CA9
SCHEMBL18030236 0.74 MEN1 (0.49) TOP1CA1CA2CA7CA9
SCHEMBL7212940 0.73 HPGD (0.41) TOP1CA1CA2CA7CA9
SCHEMBL7823178 0.73 L3MBTL1 (0.47) TOP1CA1CA2CA7CA9
SCHEMBL9441197 0.73 MAPT (0.43) TOP1CA1CA2CA7CA9
SCHEMBL28148154 0.72 CA1 (0.65) TOP1CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0530335-B1 DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS HOFFMANN LA ROCHE (CH) 1996-08-14 EP claimed
US-5302738-A Chiral phosphines HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US claimed
EP-0667350-B1 Water-soluble phosphine-derivatives HOFFMANN LA ROCHE (CH) 1999-09-01 EP disclosed
EP-0579797-B1 DIPHOSPHINE LIGANDS HOFFMANN LA ROCHE (CH) 1999-04-21 EP disclosed
EP-0530335-B1 DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS HOFFMANN LA ROCHE (CH) 1996-08-14 EP disclosed
US-5536858-A CATALYSTS FOR HYDROGENATION USING PHOSPHINEARYLSULFONATES HOFFMANN-LA ROCHE INC. (US) 1996-07-16 US disclosed
EP-0530336-B1 CHIRAL PHOSPHINES HOFFMANN LA ROCHE (CH) 1996-03-06 EP disclosed
US-5457219-A Used in making hydrogenation catalysts and isomerization catalysts HOFFMANN-LA ROCHE INC. (US) 1995-10-10 US disclosed
EP-0667350-A1 Water-soluble phosphine-derivatives F. HOFFMANN-LA ROCHE AG (CH) 1995-08-16 EP disclosed
US-5302738-A Chiral phosphines HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US disclosed
US-5274125-A Chirale phosphines HOFFMANN-LA ROCHE INC. (US) 1993-12-28 US disclosed
EP-0530335-A1 DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS. HOFFMANN LA ROCHE (CH) 1993-03-10 EP disclosed
EP-0530336-A1 CHIRAL PHOSPHINES. HOFFMANN LA ROCHE (CH) 1993-03-10 EP disclosed
WO-1992016536-A1 CHIRAL PHOSPHINES F. HOFFMANN-LA ROCHE AG (CH) 1992-10-01 WO disclosed
WO-1992016535-A1 DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS F.HOFFMANN-LA ROCHE AG (CH) 1992-10-01 WO disclosed