Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319708 | 0.78 | DYRK1B (0.40) | DYRK1ADYRK1BRETLRRK2CDK9 | |
| SCHEMBL21806796 | 0.75 | DYRK1A (0.38) | DYRK1ADYRK1BRETLRRK2CDK9 | |
| SCHEMBL15726869 | 0.75 | PIM1 (0.45) | DYRK1ADYRK1BRETLRRK2CDK9 | |
| SCHEMBL23199596 | 0.75 | DYRK1B (0.45) | DYRK1ADYRK1BRETLRRK2CDK9 | |
| SCHEMBL8327596 | 0.75 | DYRK1A (0.38) | DYRK1ADYRK1BRETLRRK2CDK9 | |
| SCHEMBL1689336 | 0.72 | CCNA2 (0.42) | DYRK1ADYRK1BRETLRRK2CDK9 | |
| SCHEMBL4697303 | 0.71 | GAA (0.48) | DYRK1ADYRK1BRETLRRK2CDK9 | |
| SCHEMBL20142243 | 0.71 | DYRK1A (0.35) | DYRK1ADYRK1B | |
| SCHEMBL15723268 | 0.71 | DYRK1A (0.35) | DYRK1ADYRK1BCDK1CCNB1HSP90AA1 | |
| SCHEMBL4779596 | 0.71 | DYRK1A (0.38) | DYRK1ADYRK1BCDK5CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353941-A2 | Medicament for psoriasis containing derivatives of 3-aminopyrazolo [3,4-d]pyrimidine | Takeda Chemical Industries, Ltd. (JP) | 1990-02-07 | — | — | EP | claimed |
| JP-2138217-A | — | — | None | — | — | JP | disclosed |
| US-20220064167-A1 | IMIDAZO-PYRAZOLE CARBOXAMIDE DERIVATIVES AS ANTICANCER AGENTS AND THE SYNTHESIS THEREOF | AVIDIN KFT. (HU) | 2022-03-03 | — | — | US | disclosed |
| EP-3883649-A1 | IMIDAZO-PYRAZOLE CARBOXAMIDE DERIVATIVES AS ANTICANCER AGENTS AND THE SYNTHESIS THEREOF | Avidin KFT (HU) | 2021-09-29 | — | — | EP | disclosed |
| WO-2014149206-A1 | PYRAZOLOPYRIMIDINE-BASED INSECTICIDAL COMPOSITIONS AND RELATED METHODS | DOW AGROSCIENCES LLC (US) | 2014-09-25 | — | — | WO | disclosed |
| EP-0496617-B1 | Adenosine kinase inhibitors | METABASIS THERAPEUTICS INC (US) | 1999-12-01 | — | — | EP | disclosed |
| EP-0682519-A4 | ADENOSINE KINASE INHIBITORS. | GENSIA INC (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0682519-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| EP-0383465-B1 | Tricyclic fused pyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-05-03 | — | — | EP | disclosed |
| EP-0353941-A2 | Medicament for psoriasis containing derivatives of 3-aminopyrazolo [3,4-d]pyrimidine | Takeda Chemical Industries, Ltd. (JP) | 1990-02-07 | — | — | EP | disclosed |
| EP-0353941-A2 | Medicament for psoriasis containing derivatives of 3-aminopyrazolo [3,4-d]pyrimidine | Takeda Chemical Industries, Ltd. (JP) | 1990-02-07 | — | — | EP | disclosed |
| EP-0166054-B1 | 3-AMINOPYRAZOLO(3,4-D)PYRIMIDINE DERIVATIVES AND PRODUCTION THEREOF | Takeda Chemical Industries, Ltd. (JP) | 1989-04-19 | — | — | EP | disclosed |
| US-4603203-A | ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| US-4603203-A | ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| US-4603203-A | ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| EP-0166054-A1 | 3-Aminopyrazolo(3,4-d)pyrimidine derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1986-01-02 | — | — | EP | disclosed |
| EP-0166054-A1 | 3-Aminopyrazolo(3,4-d)pyrimidine derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1986-01-02 | — | — | EP | disclosed |
| EP-0166054-A1 | 3-Aminopyrazolo(3,4-d)pyrimidine derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1986-01-02 | — | — | EP | disclosed |
| US-4292391-A | PYRAZOLO/3,4-D/PYRIMIDINES; PHOTOLITHOGRAPHY | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064167-A1 | IMIDAZO-PYRAZOLE CARBOXAMIDE DERIVATIVES AS ANTICANCER AGENTS AND THE SYNTHESIS THEREOF | MYD88, MCL1, MYADM | DYRK1A 1419/4885DYRK1B 1801/4885RET 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.