Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.58 |
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408143 | 0.84 | SPHK2 (0.63) | SPHK2SPHK1BRD4LMNAHDAC6 | |
| SCHEMBL8324158 | 0.84 | PTGER1 (0.61) | MAPTKDM4EALDH1A1KMT2APPIA | |
| SCHEMBL8322962 | 0.83 | SPHK2 (0.58) | SPHK2SPHK1BRD4LMNAHDAC6 | |
| SCHEMBL8320173 | 0.82 | KMT2A (0.60) | LMNAHTTMAPTALDH1A1RAB9A | |
| SCHEMBL8325162 | 0.77 | PTGER1 (0.69) | MAPTKDM4EALDH1A1KMT2APPIA | |
| SCHEMBL8323273 | 0.77 | SPHK2 (0.59) | SPHK2SPHK1BRD4MAPTRAB9A | |
| SCHEMBL7296744 | 0.76 | SPHK2 (0.80) | SPHK2SPHK1BRD4LMNAHTT | |
| SCHEMBL8320496 | 0.76 | KMT2A (0.57) | LMNAHTTMAPTALDH1A1RAB9A | |
| SCHEMBL14704514 | 0.75 | BRD4 (0.72) | SPHK2SPHK1BRD4HDAC6KDM4E | |
| SCHEMBL30216939 | 0.75 | BRD4 (0.72) | SPHK2SPHK1BRD4HDAC6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |