Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325122 | 0.85 | POLB (0.56) | RAB9AKMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL8408143 | 0.84 | SPHK2 (0.63) | SPHK2SPHK1RAB9ABRD4KMT2A | |
| SCHEMBL8322839 | 0.84 | PTGER4 (0.57) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8328813 | 0.83 | SPHK2 (0.58) | SPHK2SPHK1RAB9ABRD4KMT2A | |
| SCHEMBL8163071 | 0.82 | HDAC2 (0.59) | SPHK2SPHK1RAB9AKMT2AMEN1 | |
| SCHEMBL8328747 | 0.82 | MAPT (0.54) | RAB9AKMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL6258710 | 0.78 | NPC1 (0.60) | SPHK2SPHK1RAB9AHDAC6NPC1 | |
| SCHEMBL8326623 | 0.77 | PTGER1 (0.69) | KMT2AMEN1SMN1; SMN2HDAC8 | |
| SCHEMBL8323273 | 0.77 | SPHK2 (0.59) | SPHK2SPHK1RAB9ABRD4KMT2A | |
| SCHEMBL7296744 | 0.76 | SPHK2 (0.80) | SPHK2SPHK1RAB9ABRD4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |