Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.63 |
| ▸ | EDNRB | P24530 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CCR9 | P51686 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326002 | 0.88 | EDNRA (0.77) | EDNRAEDNRBCCR9 | |
| SCHEMBL8328948 | 0.81 | MAPT (0.52) | KMT2AMEN1KDM4EGAAPIK3CA | |
| SCHEMBL7006085 | 0.80 | EDNRA (0.77) | EDNRAEDNRBKMT2AMEN1CCR9 | |
| SCHEMBL9091404 | 0.80 | EDNRA (0.58) | EDNRAEDNRB | |
| SCHEMBL7006427 | 0.80 | EDNRA (0.81) | EDNRAEDNRBKMT2AMEN1CCR9 | |
| SCHEMBL7009309 | 0.80 | EDNRA (0.76) | EDNRAEDNRBKMT2AMEN1CCR9 | |
| SCHEMBL7008931 | 0.79 | EDNRA (0.74) | EDNRAEDNRBKMT2AMEN1CCR9 | |
| SCHEMBL9157048 | 0.77 | EDNRA (0.73) | EDNRAEDNRBKMT2AMEN1KDM4E | |
| SCHEMBL7013111 | 0.76 | EDNRA (0.80) | EDNRAEDNRBKMT2AMEN1 | |
| SCHEMBL6781031 | 0.76 | EDNRA (0.71) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |