Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27323813 | 0.85 | MAPT (0.46) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL8328877 | 0.81 | EDNRA (0.63) | MAPTPIK3CAMEN1KMT2AKDM4E | |
| SCHEMBL7011083 | 0.74 | MAPT (0.50) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL2375785 | 0.73 | PIK3CA (0.58) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12248550 | 0.73 | MAPT (0.51) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL23537562 | 0.72 | MAPT (0.58) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4064654 | 0.72 | L3MBTL1 (0.52) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL14147277 | 0.71 | PIK3CD (0.50) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL2376492 | 0.71 | PIK3CA (0.55) | MAPTL3MBTL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL11862853 | 0.71 | HTT (0.56) | MEN1KMT2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |