Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8331150 | 0.99 | MAPT (0.52) | MAPTGAAPOLBTP53SMN1; SMN2 | |
| SCHEMBL8326516 | 0.89 | MEN1 (0.46) | MAPTGAAPOLBSMN1; SMN2PAX8 | |
| SCHEMBL8561277 | 0.89 | PDE4B (0.61) | MAPTGAATP53SMN1; SMN2PDE4B | |
| Hydrochloric Acid SCHEMBL8563873 | 0.88 | PDE4B (0.60) | MAPTGAATP53SMN1; SMN2PDE4B | |
| SCHEMBL8327883 | 0.87 | MAPT (0.48) | MAPTGAATP53SMN1; SMN2PDE4B | |
| Hydrochloric Acid SCHEMBL8327246 | 0.86 | MAPT (0.47) | MAPTGAATP53SMN1; SMN2PDE4B | |
| SCHEMBL8326159 | 0.83 | MAPT (0.52) | MAPTGAATP53SMN1; SMN2PAX8 | |
| Hydrochloric Acid SCHEMBL8330067 | 0.82 | MAPT (0.51) | MAPTGAATP53SMN1; SMN2PAX8 | |
| SCHEMBL8327448 | 0.79 | NPC1 (0.44) | MAPTGAATP53SMN1; SMN2NPC1 | |
| SCHEMBL8322999 | 0.78 | KMT2A (0.58) | MAPTPOLBTP53SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | claimed |
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |