Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 15/20 | 0.54 |
| ▸ | RARB | P10826 | 13/20 | 0.54 |
| ▸ | RARA | P10276 | 12/20 | 0.54 |
| ▸ | RXRA | P19793 | 5/20 | 0.50 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356134 | 0.77 | RARG (0.64) | RARGRARBRARARXRARXRB | |
| SCHEMBL9856398 | 0.76 | RARB (0.62) | RARGRARBRARARXRARXRB | |
| SCHEMBL5846340 | 0.75 | RARB (0.77) | RARGRARBRARARXRARXRB | |
| SCHEMBL9551739 | 0.74 | RARB (0.69) | RARGRARBRARARXRARXRB | |
| SCHEMBL8679596 | 0.74 | RARB (0.52) | RARGRARBRARARXRARXRB | |
| SCHEMBL9856250 | 0.73 | RARB (0.53) | RARGRARBRARARXRARXRB | |
| SCHEMBL9856315 | 0.72 | RARG (0.50) | RARGRARBRARARXRARXRB | |
| SCHEMBL10549628 | 0.71 | RARG (0.57) | RARGRARBRARARXRARXRB | |
| SCHEMBL2331952 | 0.70 | RARB (1.00) | RARGRARBRARARXRARXRB | |
| SCHEMBL14437917 | 0.70 | RARB (1.00) | RARGRARBRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856490-A | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity | ALLERGAN (US) | 1999-01-05 | — | — | US | claimed |
| US-5856490-A | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity | ALLERGAN (US) | 1999-01-05 | — | — | US | disclosed |