Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12172321 | 0.74 | CHRM2 (0.36) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL7334201 | 0.71 | CHRM2 (0.44) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL8465314 | 0.71 | ALDH1A1 (0.33) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8465242 | 0.71 | ALDH1A1 (0.36) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8328123 | 0.71 | ALDH1A1 (0.36) | CHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL8323657 | 0.70 | ALDH1A1 (0.33) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL26330098 | 0.69 | CYP19A1 (0.39) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL25500893 | 0.69 | CHRM2 (0.42) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL14000229 | 0.67 | CHRM2 (0.37) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL113630 | 0.67 | MEN1 (0.37) | CHRM2CHRM4CHRM1CHRM3CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789571-A4 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO INC (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0789571-A1 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Merck & Co., Inc. (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1996014844-A1 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-05-23 | — | — | WO | disclosed |