Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 1.00 |
| ▸ | NOS1 | P29475 | 1/20 | 1.00 |
| ▸ | NOS2 | P35228 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 17/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BPTF | Q12830 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 9/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30471705 | 0.96 | NOS3 (0.92) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL527227 | 0.78 | NOS3 (0.64) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL29621658 | 0.78 | NOS3 (0.64) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL20417066 | 0.77 | NOS3 (0.62) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL4926313 | 0.75 | NOS3 (0.60) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL4928326 | 0.75 | NOS3 (0.60) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL9753025 | 0.74 | NOS3 (0.59) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL20416983 | 0.74 | NOS3 (0.59) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL25807047 | 0.72 | NOS3 (0.56) | NOS3NOS1NOS2KDM4EACHE | |
| SCHEMBL19998979 | 0.72 | NOS3 (0.56) | NOS3NOS1NOS2KDM4EACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1290249-A | Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-04-04 | — | — | CN | disclosed |
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |
| WO-1991017979-A1 | PROCESS FOR THE PREPARATION OF 2-N-ACYLAMINOPYRIDINES AND 2-AMINOPYRIDINES FROM 5-OXOALKANENITRILE OXIMES | DSM N.V. (NL) | 1991-11-28 | — | — | WO | disclosed |