Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.64 |
| ▸ | XIAP | P98170 | 9/20 | 0.43 |
| ▸ | NPY1R | P25929 | 5/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791654 | 0.93 | GHSR (0.54) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL8331869 | 0.92 | GHSR (0.76) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL7786006 | 0.90 | GHSR (0.52) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL7785743 | 0.88 | GHSR (0.69) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL7795550 | 0.88 | GHSR (0.83) | GHSRXIAPNPY1RAGTR1 | |
| SCHEMBL8330387 | 0.86 | GHSR (0.76) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL8330101 | 0.86 | GHSR (0.66) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL8330701 | 0.86 | GHSR (0.67) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL8330710 | 0.86 | GHSR (0.76) | GHSRXIAPNPY1RPTGER1PTGER4 | |
| SCHEMBL8329246 | 0.85 | GHSR (0.69) | GHSRXIAPNPY1RPTGER1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |