SCHEMBL8332364

SCHEMBL8332364

OCc1ccc(-c2n[nH]c3cccc(Cc4ccccc4F)c23)o1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE5A O76074 4/20 0.41
FFAR1 O14842 1/20 0.35
GPR84 Q9NQS5 1/20 0.35
MAP2K4 P45985 3/20 0.34
HIF1A Q16665 4/20 0.34
EPAS1 Q99814 4/20 0.34
KDM4E B2RXH2 3/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPT P10636 2/20 0.34
MAPK1 P28482 2/20 0.34
NPC1 O15118 1/20 0.34
GMNN O75496 1/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8327929 0.89 PDE5A (0.37) PDE5AMAP2K4HIF1AEPAS1KDM4E
SCHEMBL8328753 0.88 PDE5A (0.37) PDE5AMAP2K4HIF1AEPAS1KDM4E
SCHEMBL163795 0.86 HIF1A (0.44) PDE5AMAP2K4HIF1AEPAS1KDM4E
SCHEMBL8330242 0.85 MAP2K4 (0.39) PDE5AMAP2K4HIF1AEPAS1KDM4E
SCHEMBL8471597 0.84 MAP2K1 (0.41) PDE5AMAP2K4HIF1AEPAS1KDM4E
SCHEMBL8327060 0.81 AR (0.35) FFAR1GPR84HIF1AKDM4EALDH1A1
SCHEMBL8328669 0.79 MAP2K4 (0.43) PDE5AMAP2K4HIF1AEPAS1KDM4E
SCHEMBL8504165 0.79 ALDH1A1 (0.37) PDE5AHIF1AEPAS1KDM4EALDH1A1
SCHEMBL8470062 0.77 CYP1A2 (0.36) PDE5AMAP2K4HIF1AEPAS1KDM4E
SCHEMBL8329920 0.77 PDE5A (0.44) PDE5AMAP2K4HIF1AEPAS1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0932403-A1 USE OF CONDENSATED (HETARYL-SUBSTITUTED) 1-BENZAL-3-PYRAZOL DERIVATES FOR TREATING SPECIAL DISEASES OF THE CARDIOVASCULAR AND THE CENTRAL NERVOUS SYSTEMS BAYER AG (DE) 1999-08-04 EP claimed
WO-1998016223-A1 USE OF CONDENSATED (HETARYL-SUBSTITUTED) 1-BENZAL-3-PYRAZOL DERIVATES FOR TREATING SPECIAL DISEASES OF THE CARDIOVASCULAR AND THE CENTRAL NERVOUS SYSTEMS BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO claimed
EP-0932403-A1 USE OF CONDENSATED (HETARYL-SUBSTITUTED) 1-BENZAL-3-PYRAZOL DERIVATES FOR TREATING SPECIAL DISEASES OF THE CARDIOVASCULAR AND THE CENTRAL NERVOUS SYSTEMS BAYER AG (DE) 1999-08-04 EP disclosed
WO-1998016223-A1 USE OF CONDENSATED (HETARYL-SUBSTITUTED) 1-BENZAL-3-PYRAZOL DERIVATES FOR TREATING SPECIAL DISEASES OF THE CARDIOVASCULAR AND THE CENTRAL NERVOUS SYSTEMS BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed