Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 3/20 | 0.42 |
| ▸ | FNTB | P49356 | 3/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8333462 | 1.00 | L3MBTL1 (0.48) | L3MBTL1CYP2C9ALDH1A1USP2METAP2 | |
| SCHEMBL8330810 | 0.87 | FNTA (0.46) | L3MBTL1CYP2C9ALDH1A1USP2METAP2 | |
| SCHEMBL8330806 | 0.87 | FNTA (0.46) | L3MBTL1CYP2C9ALDH1A1USP2METAP2 | |
| SCHEMBL8333718 | 0.86 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL13093070 | 0.86 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL2550265 | 0.86 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL2550262 | 0.86 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL8241609 | 0.85 | BIRC2 (0.40) | CYP2C9ALDH1A1TAS1R3TAS1R1CYP2C19 | |
| SCHEMBL8238371 | 0.85 | BIRC2 (0.40) | CYP2C9ALDH1A1TAS1R3TAS1R1CYP2C19 | |
| Hydrochloric Acid SCHEMBL8865857 | 0.85 | MME (0.51) | L3MBTL1CYP2C9ALDH1A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730467-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0730467-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5468733-A | FOR TREATING CANCER | MERCK & CO., INC. (US) | 1995-11-21 | — | — | US | disclosed |
| WO-1995009000-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1995-04-06 | — | — | WO | disclosed |