Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835762 | 0.88 | HPGD (0.50) | UCHL1HPGDDDB1CRBNNAMPT | |
| SCHEMBL834021 | 0.83 | UCHL1 (0.64) | HSD11B1UCHL1DDB1CRBNUSP30 | |
| SCHEMBL3055188 | 0.83 | DDB1 (0.52) | ALDH1A1UCHL1DDB1CRBNNAMPT | |
| SCHEMBL31420680 | 0.83 | DDB1 (0.52) | ALDH1A1UCHL1DDB1CRBNNAMPT | |
| SCHEMBL24265580 | 0.80 | MAPK1 (0.49) | ALDH1A1MEN1MAPTKMT2AUCHL1 | |
| SCHEMBL29574543 | 0.80 | MAPK1 (0.46) | ALDH1A1MEN1MAPTKMT2AUCHL1 | |
| SCHEMBL7641200 | 0.78 | ESR2 (0.52) | ALDH1A1MAPTUCHL1DDB1CRBN | |
| SCHEMBL2121713 | 0.78 | ESR2 (0.52) | ALDH1A1MAPTUCHL1DDB1CRBN | |
| SCHEMBL834779 | 0.76 | MEN1 (0.45) | ALDH1A1MEN1MAPTKMT2AHSD11B1 | |
| SCHEMBL17866332 | 0.76 | MEN1 (0.54) | ALDH1A1MEN1MAPTKMT2AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143284-B2 | 2-cyclohexyl-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide; allergic encephalitis, arthritis, cardiac and kidney toxicities from doxorubicin-based and platinum-based antineoplastic agents, carcinoma of the breast, central nervous system inflammation, cervical carcinoma, | ABBOTT LABORATORIES (US) | 2012-03-27 | — | — | US | disclosed |
| US-20080108659-A1 | POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | ABBVIE INC. | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108659-A1 | POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP11, PARP2 | ALDH1A1 1374/4885MEN1 4007/4885MAPT 2075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.