Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334150 | 0.85 | MAPT (0.58) | MAPTSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL9073439 | 0.85 | MAPT (1.00) | MAPTSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL17179367 | 0.78 | MAPT (1.00) | MAPTSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL44801 | 0.75 | CYP2C19 (1.00) | MAPTSMN1; SMN2KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL10849799 | 0.71 | MAPT (0.66) | MAPTSMN1; SMN2KMT2APOLBPKM | |
| SCHEMBL9156307 | 0.69 | ALDH1A1 (0.68) | MAPTSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL17179275 | 0.68 | MAPT (0.78) | MAPTSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL21420146 | 0.68 | MAPT (0.78) | MAPTSMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL8707975 | 0.68 | HPGD (0.51) | SMN1; SMN2KMT2AMEN1NPSR1CYP2C19 | |
| SCHEMBL7716565 | 0.68 | CYP2C19 (0.70) | MAPTSMN1; SMN2KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783318-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-10-20 | — | — | EP | disclosed |
| EP-0783318-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009836-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |