⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4625511 | 0.76 | — | — | |
| SCHEMBL834933 | 0.69 | — | — | |
| SCHEMBL835552 | 0.66 | — | — | |
| SCHEMBL578645 | 0.65 | — | — | |
| SCHEMBL3679400 | 0.63 | TSHR (0.46) | — | |
| SCHEMBL14968279 | 0.63 | — | — | |
| SCHEMBL562402 | 0.63 | — | — | |
| SCHEMBL20636796 | 0.63 | — | — | |
| SCHEMBL831671 | 0.60 | — | — | |
| SCHEMBL583176 | 0.60 | ALDH1A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877321-A | NEUROKININ RECEPTOR | SANOFI (FR) | 1999-03-02 | — | — | US | claimed |
| US-11541023-B2 | Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases | SARBONNE UNIVERSITE (FR) | 2023-01-03 | — | — | US | disclosed |
| US-20210046026-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY DISEASES | SORBONNE UNIVERSITE (FR) | 2021-02-18 | — | — | US | disclosed |
| EP-3752138-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY DISEASES | SORBONNE UNIVERSITE (FR) | 2020-12-23 | — | — | EP | disclosed |
| US-8497397-B2 | Substituted acrylamide derivative and pharmaceutical composition comprising the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-30 | — | — | US | disclosed |
| EP-1880720-B1 | SUBSTITUTED ACRYLAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAIICHI SANKYO CO LTD (JP) | 2013-02-13 | — | — | EP | disclosed |
| US-8344029-B2 | Substituted propanamide derivative and pharmaceutical composition containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20120220593-A1 | Substituted Acrylamide Derivative and Pharmaceutical Composition Comprising the Same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| US-8143446-B2 | Substituted acrylamide derivative and pharmaceutical composition comprising the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-27 | — | — | US | disclosed |
| US-20090292024-A1 | SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
| EP-0239129-A2 | Hydroquinoline compounds, compositions containing same and processes for preparing same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-30 | — | — | EP | disclosed |
| US-4668783-A | Thiazolylacetamido cephalosporin compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-05-26 | — | — | US | disclosed |
| EP-0206000-A1 | (2,3)-Alpha-methylenepenam-3-carboxylic acids and derivatives thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1986-12-30 | — | — | EP | disclosed |
| US-4514565-A | Thiazolylacetamido cephalosphorin compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-04-30 | — | — | US | disclosed |
| US-4355160-A | Thiazolylacetamido cephalosporin type compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-10-19 | — | — | US | disclosed |
| EP-0045198-A2 | 1,1-Disubstituted carba-2-penems and their production | Takeda Chemical Industries, Ltd. (JP) | 1982-02-03 | — | — | EP | disclosed |
| US-4298606-A | Thiazolylacetamido compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-11-03 | — | — | US | disclosed |
| US-4205180-A | CHEMICAL INTERMEDIATES FOR NOVEL CEPHALOSPORIN COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-05-27 | — | — | US | disclosed |
| US-4203899-A | Thiazolylacetamido compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-05-20 | — | — | US | disclosed |
| US-4098888-A | THIAZOLYLACETAMIDO CEPHALOSPORIN TYPE COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1978-07-04 | — | — | US | disclosed |