Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334594 | 0.89 | TSHR (0.49) | CTSKCTSLCTSBCTSSTSHR | |
| SCHEMBL13078610 | 0.88 | CTSK (0.51) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL1414212 | 0.87 | CTSK (0.48) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL1414210 | 0.87 | CTSK (0.48) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL10076126 | 0.87 | CTSK (0.50) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL13044376 | 0.85 | CTSK (0.47) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL6464254 | 0.85 | CTSK (0.49) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL3741937 | 0.84 | CTSK (0.50) | CTSKCTSLCTSBUSP2SMN1; SMN2 | |
| SCHEMBL3746299 | 0.82 | PPARA (0.62) | CTSLCTSSKMT2AMAPK1 | |
| SCHEMBL25177957 | 0.82 | CTSK (0.48) | CTSKCTSLCTSBUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052851-A1 | PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2004-06-24 | — | — | WO | disclosed |