Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8333474 | 0.92 | NPSR1 (0.33) | ALDH1A1RECQLKCNH2HIF1ALMNA | |
| SCHEMBL8338169 | 0.91 | HIF1A (0.34) | HIF1ASMN1; SMN2QPCT | |
| SCHEMBL8336116 | 0.90 | SMN1; SMN2 (0.35) | ALDH1A1HIF1ALMNATP53MAPT | |
| SCHEMBL8340153 | 0.89 | SMN1; SMN2 (0.35) | ALDH1A1HIF1AMAPTSMN1; SMN2GAA | |
| SCHEMBL8336974 | 0.89 | SMPD1 (0.34) | SMN1; SMN2GAA | |
| SCHEMBL8335988 | 0.89 | SMPD1 (0.34) | SMN1; SMN2GAA | |
| SCHEMBL8334645 | 0.89 | SMPD1 (0.34) | SMN1; SMN2GAA | |
| SCHEMBL8333752 | 0.87 | HIF1A (0.34) | ALDH1A1HIF1ALMNATP53MAPT | |
| SCHEMBL8336357 | 0.87 | HIF1A (0.34) | ALDH1A1HIF1ALMNATP53MAPT | |
| SCHEMBL8335857 | 0.86 | GAA (0.31) | ALDH1A1HIF1ALMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |