Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336542 | 0.90 | PTGS2 (0.32) | PTGS2HIF1AAKR1C3AKR1C2 | |
| SCHEMBL8334835 | 0.89 | GAA (0.31) | GAAALDH1A1PTGS2HIF1AAKR1C3 | |
| SCHEMBL8334767 | 0.86 | ALDH1A1 (0.33) | GAAALDH1A1HIF1AKMT2ALMNA | |
| SCHEMBL8333752 | 0.85 | HIF1A (0.34) | ALDH1A1HIF1ALMNASMN1; SMN2 | |
| SCHEMBL8336357 | 0.85 | HIF1A (0.34) | ALDH1A1HIF1ALMNASMN1; SMN2 | |
| SCHEMBL8334478 | 0.85 | BCHE (0.30) | — | |
| SCHEMBL8333474 | 0.85 | NPSR1 (0.33) | GAAALDH1A1HIF1ALMNASMN1; SMN2 | |
| SCHEMBL8389248 | 0.84 | TAS1R3 (0.32) | ALDH1A1HIF1ALMNASMN1; SMN2 | |
| SCHEMBL8336116 | 0.83 | SMN1; SMN2 (0.35) | GAAALDH1A1HIF1AKMT2ALMNA | |
| SCHEMBL8339599 | 0.82 | TSHR (0.36) | GAAALDH1A1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |