Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 16/20 | 0.74 |
| ▸ | CDK5R1 | Q15078 | 16/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ATP4A | P20648 | 1/20 | 0.47 |
| ▸ | ATP4B | P51164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5901418 | 0.85 | CDK5 (1.00) | CDK5CDK5R1 | |
| SCHEMBL5902427 | 0.85 | CDK5 (0.85) | CDK5CDK5R1 | |
| SCHEMBL8324986 | 0.83 | CDK5 (0.75) | CDK5CDK5R1ALDH1A1GAA | |
| SCHEMBL5901558 | 0.83 | CDK5 (0.81) | CDK5CDK5R1 | |
| SCHEMBL5902111 | 0.83 | CDK5 (0.78) | CDK5CDK5R1MAPTALDH1A1LMNA | |
| SCHEMBL5901524 | 0.83 | CDK5 (0.71) | CDK5CDK5R1MAPTALDH1A1LMNA | |
| SCHEMBL5902446 | 0.83 | CDK5 (0.71) | CDK5CDK5R1MAPTALDH1A1LMNA | |
| SCHEMBL5902540 | 0.83 | CDK5 (0.80) | CDK5CDK5R1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8335335 | 0.82 | CDK5 (0.81) | CDK5CDK5R1 | |
| SCHEMBL5901425 | 0.81 | CDK5 (0.66) | CDK5CDK5R1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060890-A1 | 2-OXOPYRIDIN-3-YL THIA (DI) AZOLE DERIVATES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | AMGEN INC. (US) | 2004-07-22 | — | — | WO | disclosed |