SCHEMBL8335877

SCHEMBL8335877

COc1ccc(-c2ccccc2)c(C(=O)c2ccccc2)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.63
HTT P42858 3/20 0.63
CYP1A2 P05177 2/20 0.63
CYP2D6 P10635 2/20 0.63
CYP2C19 P33261 2/20 0.63
LMNA P02545 2/20 0.63
HPGD P15428 2/20 0.63
PGR P06401 1/20 0.63
SLC6A2 P23975 1/20 0.63
PDE4A P27815 1/20 0.63
MAPK1 P28482 1/20 0.63
HRH1 P35367 1/20 0.63
SLC6A3 Q01959 1/20 0.63
PDE4D Q08499 1/20 0.63
SMN1; SMN2 Q16637 5/20 0.62
CYP2C8 P10632 2/20 0.60
KDM4E B2RXH2 5/20 0.56
CYP2C9 P11712 2/20 0.56
MAPT P10636 2/20 0.55
NPSR1 Q6W5P4 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8333549 0.95 ALDH1A1 (0.68) ALDH1A1HTTCYP1A2CYP2D6CYP2C19
SCHEMBL8340026 0.93 CYP2C8 (0.71) ALDH1A1HTTCYP1A2CYP2D6CYP2C19
SCHEMBL30739535 0.88 ALDH1A1 (0.68) ALDH1A1HTTCYP1A2CYP2D6CYP2C19
SCHEMBL5342329 0.85 SMN1; SMN2 (0.84) ALDH1A1CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL8340469 0.85 ALDH1A1 (0.52) ALDH1A1HTTCYP1A2CYP2D6CYP2C19
SCHEMBL9697885 0.84 HCRTR1 (0.69) ALDH1A1LMNAHPGDMAPK1SMN1; SMN2
SCHEMBL8333686 0.84 SMN1; SMN2 (0.57) ALDH1A1HTTCYP1A2CYP2D6CYP2C19
SCHEMBL8338154 0.83 SMN1; SMN2 (0.71) ALDH1A1HTTCYP1A2CYP2D6CYP2C19
SCHEMBL5311021 0.83 KDM4E (0.82) CYP1A2CYP2D6CYP2C19SLC6A2SLC6A3
SCHEMBL13356437 0.83 SMN1; SMN2 (0.62) ALDH1A1HTTCYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999007694-A1 COMPOUNDS AND USES THEREOF ELI LILLY AND COMPANY (US) 1999-02-18 WO disclosed
US-5847168-A Photochromic compounds VISION-EASE LENS, INC. (US) 1998-12-08 US disclosed
US-5846531-A Marine mela gene UNIVERSITY OF MARYLAND (US) 1998-12-08 US disclosed
US-5840926-A PHOTOCHROMIC ARTICLE COMPRISING HOST MATERIAL AND PHOTOCHROMIC NAPHTHOPYRAN COMPOUND VISION-EASE LENS, INC. (US) 1998-11-24 US disclosed
EP-0653208-A2 Pharmaceutical agents for treatment or prevention of sunburn PFIZER INC. (US) 1995-05-17 EP disclosed
EP-0552289-A4 PREVENTION OR TREATMENT OF SUNBURN USING THE S(+) ISOMER OF KETOPROFEN 1993-08-11 EP disclosed
EP-0552289-A1 PREVENTION OR TREATMENT OF SUNBURN USING THE S(+) ISOMER OF KETOPROFEN MILES INC. (US) 1993-07-28 EP disclosed
WO-1992005769-A1 PREVENTION OR TREATMENT OF SUNBURN USING THE S(+) ISOMER OF KETOPROFEN MILES, INC. (US) 1992-04-16 WO disclosed
US-5100918-A Prevention or treatment of sunburn using the S(+) isomer of ibuprofen STERLING DRUG, INC. (US) 1992-03-31 US disclosed
WO-1991017740-A1 PREVENTION OR TREATMENT OF SUNBURN USING THE S(+) ISOMER OF FLURBIPROFEN ANALGESIC ASSOCIATES (US) 1991-11-28 WO disclosed