Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340378 | 0.94 | HTT (0.44) | HTTTDP1EPHX2ALDH1A1KMT2A | |
| SCHEMBL8340007 | 0.91 | TDP1 (0.49) | HTTTDP1EPHX2ALDH1A1KMT2A | |
| SCHEMBL8335999 | 0.85 | TDP1 (0.51) | HTTTDP1EPHX2ALDH1A1KMT2A | |
| SCHEMBL8336596 | 0.80 | TDP1 (0.53) | HTTTDP1EPHX2ALDH1A1KMT2A | |
| SCHEMBL8340529 | 0.73 | TDP1 (0.44) | HTTTDP1EPHX2ALDH1A1KMT2A | |
| SCHEMBL8337202 | 0.73 | HPGD (0.39) | HTTTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL10928682 | 0.68 | HTT (0.63) | HTTTDP1EPHX2ALDH1A1KMT2A | |
| SCHEMBL8338584 | 0.68 | HPGD (0.40) | HTTTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3369060 | 0.67 | HTT (0.76) | HTTTDP1EPHX2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL10932165 | 0.67 | HTT (0.61) | HTTTDP1EPHX2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |