Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 18/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8843004 | 0.84 | SIGMAR1 (0.64) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8332178 | 0.78 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL7786668 | 0.76 | SIGMAR1 (0.39) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6721226 | 0.76 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6720818 | 0.75 | SIGMAR1 (0.81) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6720799 | 0.73 | SIGMAR1 (0.64) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL7406514 | 0.73 | SIGMAR1 (1.00) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6724356 | 0.73 | SIGMAR1 (0.82) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL17678535 | 0.73 | SIGMAR1 (0.60) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6725035 | 0.72 | SIGMAR1 (0.62) | SIGMAR1TP53CYP2D6TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | claimed |
| EP-0918460-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998004131-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-02-05 | — | — | WO | disclosed |