Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19347551 | 0.98 | TSHR (0.42) | TSHRTHRBMAPTGALR3BLM | |
| Bromide SCHEMBL27800223 | 0.96 | TSHR (0.41) | TSHRTHRBMAPTGALR3BLM | |
| Hydrochloric Acid SCHEMBL27482890 | 0.87 | TSHR (0.35) | TSHRTHRBMAPTGALR3BLM | |
| Hydrochloric Acid SCHEMBL28053346 | 0.85 | TSHR (0.41) | TSHRTHRBMAPTGALR3BLM | |
| SCHEMBL2022220 | 0.83 | TSHR (0.42) | TSHRTHRBMAPTGALR3BLM | |
| Hydrochloric Acid SCHEMBL1426634 | 0.83 | TSHR (0.42) | TSHRTHRBMAPTGALR3BLM | |
| Bromide SCHEMBL28749870 | 0.81 | TSHR (0.41) | TSHRTHRBMAPTGALR3BLM | |
| SCHEMBL1044532 | 0.81 | TSHR (0.44) | TSHRTHRBMAPTGALR3BLM | |
| Hydrochloric Acid SCHEMBL28836358 | 0.80 | TSHR (0.50) | TSHRTHRBMAPTBLMLMNA | |
| Hydrochloric Acid SCHEMBL15953 | 0.80 | TSHR (0.42) | TSHRTHRBMAPTGALR3BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900299-A1 | COMPOSITIONS AND METHODS FOR INHIBITING DEPOSITS IN PULP AND PAPERMAKING SYSTEMS | BetzDearborn Inc (US) | 1999-03-10 | — | — | EP | claimed |
| EP-0900299-A4 | — | — | 1999-03-10 | — | — | EP | claimed |
| WO-1997044519-A1 | COMPOSITIONS AND METHODS FOR INHIBITING DEPOSITS IN PULP AND PAPERMAKING SYSTEMS | BETZDEARBORN INC. (US) | 1997-11-27 | — | — | WO | claimed |
| EP-0900299-A1 | COMPOSITIONS AND METHODS FOR INHIBITING DEPOSITS IN PULP AND PAPERMAKING SYSTEMS | BetzDearborn Inc (US) | 1999-03-10 | — | — | EP | disclosed |
| EP-0900299-A4 | — | — | 1999-03-10 | — | — | EP | disclosed |
| WO-1997044519-A1 | COMPOSITIONS AND METHODS FOR INHIBITING DEPOSITS IN PULP AND PAPERMAKING SYSTEMS | BETZDEARBORN INC. (US) | 1997-11-27 | — | — | WO | disclosed |
| EP-0000628-A1 | Process of preparing hydrophilic polyolefin fibers, the fibers so produced, and paper containing said fibers. | HERCULES INCORPORATED (US) | 1979-02-07 | — | — | EP | disclosed |