Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8050599 | 0.91 | FFAR3 (0.47) | LMNAALDH1A1TSHRHSD17B10FFAR3 | |
| Acrylic Acid SCHEMBL29206793 | 0.88 | LMNA (0.62) | LMNAALDH1A1TSHRALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL29502206 | 0.88 | LMNA (0.71) | LMNAALDH1A1TSHRALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL27615806 | 0.88 | LMNA (0.71) | LMNAALDH1A1TSHRALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL30431258 | 0.88 | LMNA (0.71) | LMNAALDH1A1TSHRALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL1147986 | 0.88 | — | — | |
| Acrylic Acid SCHEMBL6557843 | 0.88 | LMNA (0.71) | LMNAALDH1A1TSHRALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL28197422 | 0.85 | LMNA (0.67) | LMNAALDH1A1TSHRALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL27674337 | 0.85 | LMNA (0.67) | LMNAALDH1A1TSHRALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL5968416 | 0.85 | LMNA (0.67) | LMNAALDH1A1TSHRALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994580-A | VAPOR-PHASE CATALYTIC OXIDATION OF PROPANE | TOAGOSEI CO., LTD. (JP) | 1999-11-30 | — | — | US | disclosed |