Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 6/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704572 | 0.87 | GAA (0.39) | GAAF10CTSKCTSLCTSB | |
| SCHEMBL8334904 | 0.86 | GAA (0.38) | GAAF10CTSKCTSLCTSB | |
| SCHEMBL8334598 | 0.85 | GAA (0.40) | GAAF10CTSKCTSLCTSB | |
| SCHEMBL4706028 | 0.84 | F10 (0.39) | F10F2KLKB1ELANEPLAT | |
| SCHEMBL8334385 | 0.81 | GAA (0.34) | GAAF10CTSKCTSLCTSB | |
| SCHEMBL5936039 | 0.75 | GAA (0.37) | GAAF10CTSKCTSLCTSB | |
| SCHEMBL5936045 | 0.75 | GAA (0.38) | GAAF10CTSKF2CCR2 | |
| SCHEMBL6564079 | 0.74 | GAA (0.40) | GAAF10CTSKF2CCR2 | |
| SCHEMBL8337166 | 0.73 | KDM4D (0.42) | F10F2KLKB1ELANESMN1; SMN2 | |
| SCHEMBL4705534 | 0.73 | F10 (0.43) | F10F2KLKB1ELANEPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-B1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |
| WO-2004052851-A1 | PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2004-06-24 | — | — | WO | disclosed |