SCHEMBL8337019

SCHEMBL8337019

CN[C@@H](Cc1ccccc1)C(=O)OO

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.50
ALDH1A1 P00352 2/20 0.49
THRB P10828 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
HSD17B10 Q99714 1/20 0.49
POLB P06746 1/20 0.48
TAAR1 Q96RJ0 2/20 0.47
SLC18A2 Q05940 1/20 0.47
SIGMAR1 Q99720 1/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
CA12 O43570 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
CA2 P00918 1/20 0.46
LMNA P02545 1/20 0.46
GLA P06280 1/20 0.46
TACR1 P25103 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8724389 0.88 ATM (0.63) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL2734812 0.88 ATM (0.63) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL3725043 0.88 ATM (0.63) ATMALDH1A1THRBCYP2C9CYP2C19
Hydrochloric Acid SCHEMBL8724387 0.86 ATM (0.61) ATMALDH1A1THRBCYP2C9CYP2C19
Hydrochloric Acid SCHEMBL7327532 0.86 ATM (0.61) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL1324552 0.85 ATM (0.49) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL2059140 0.85 TACR1 (0.58) ALDH1A1POLBTACR1ITGA4ITGB7
SCHEMBL1093320 0.85 ATM (0.49) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL4765072 0.85 MMP8 (0.59) ATMALDH1A1THRBCYP2C9CYP2C19
SCHEMBL28803420 0.85 ATM (0.49) ATMALDH1A1THRBCYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787140-A4 PROCESS FOR PERFORMING RETRO-ALDOL REACTION LILLY CO ELI (US) 1999-04-14 EP disclosed
EP-0787140-A1 PROCESS FOR PERFORMING RETRO-ALDOL REACTION ELI LILLY AND COMPANY (US) 1997-08-06 EP disclosed
WO-1996015142-A1 PROCESS FOR PERFORMING RETRO-ALDOL REACTION ELI LILLY AND COMPANY (US) 1996-05-23 WO disclosed