Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337386 | 0.94 | LRRK2 (0.49) | LRRK2ABCG2KIFC1POLBCAPN1 | |
| SCHEMBL5927497 | 0.93 | LRRK2 (0.51) | LRRK2ABCG2KIFC1POLBMEN1 | |
| SCHEMBL8337501 | 0.92 | LRRK2 (0.47) | LRRK2ABCG2KIFC1POLBCTSB | |
| SCHEMBL5926743 | 0.91 | ABCG2 (0.52) | LRRK2ABCG2KIFC1POLBMEN1 | |
| SCHEMBL8337545 | 0.86 | LRRK2 (0.38) | LRRK2ABCG2KIFC1POLBITGB1 | |
| SCHEMBL5927425 | 0.85 | KIFC1 (0.50) | LRRK2ABCG2KIFC1POLBMEN1 | |
| SCHEMBL8337242 | 0.85 | LRRK2 (0.37) | LRRK2ABCG2KIFC1POLBCAPN1 | |
| SCHEMBL5927055 | 0.85 | KIFC1 (0.55) | LRRK2ABCG2KIFC1MEN1RECQL | |
| SCHEMBL8337866 | 0.85 | PTPN11 (0.44) | LRRK2ABCG2POLBITGB1ITGA4 | |
| SCHEMBL5926387 | 0.84 | ABCG2 (0.56) | LRRK2ABCG2KIFC1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014844-A2 | ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION | TRANSTECH PHARMA, INC. (US) | 2004-02-19 | — | — | WO | disclosed |