SCHEMBL8337467

SCHEMBL8337467

COc1cc(-n2ccnc2)cc(OC)c1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.51
CYP11B2 P19099 2/20 0.51
CYP19A1 P11511 1/20 0.50
TUBB4A P04350 2/20 0.47
TUBB P07437 2/20 0.47
TUBA3C P0DPH7 2/20 0.47
TUBA1B P68363 2/20 0.47
TUBA4A P68366 2/20 0.47
TUBB4B P68371 2/20 0.47
TUBB3 Q13509 2/20 0.47
TUBB2A Q13885 2/20 0.47
TUBB8 Q3ZCM7 2/20 0.47
TUBA3E Q6PEY2 2/20 0.47
TUBA1A Q71U36 2/20 0.47
TUBA1C Q9BQE3 2/20 0.47
TUBB6 Q9BUF5 2/20 0.47
TUBB2B Q9BVA1 2/20 0.47
TUBB1 Q9H4B7 2/20 0.47
MAOA P21397 1/20 0.45
MAOB P27338 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8727404 0.84 CYP11B1 (0.50) CYP11B1CYP11B2CYP19A1MAOAMAOB
SCHEMBL2091106 0.82 CYP11B1 (0.51) CYP11B1CYP11B2CYP19A1MAOAMAOB
SCHEMBL21295831 0.82 TUBB1 (0.43) CYP11B1CYP11B2CYP19A1TUBB4ATUBB
SCHEMBL20854613 0.81 CYP11B1 (0.62) CYP11B1CYP11B2CYP19A1MAOAMAOB
Benzene SCHEMBL27999058 0.78 CYP11B1 (0.59) CYP11B1CYP11B2CYP19A1MAOAMAOB
SCHEMBL1911845 0.78 CYP11B1 (0.59) CYP11B1CYP11B2CYP19A1MAOAMAOB
SCHEMBL14483736 0.78 CYP11B1 (0.68) CYP11B1CYP11B2CYP19A1MAOAMAOB
SCHEMBL31138008 0.78 CYP11B1 (0.68) CYP11B1CYP11B2CYP19A1MAOAMAOB
SCHEMBL15476227 0.77 CYP11B1 (0.57) CYP11B1CYP11B2CYP19A1MAOAMAOB
SCHEMBL12586939 0.77 CYP11B1 (0.57) CYP11B1CYP11B2CYP19A1MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999009845-A1 IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-04 WO claimed
CN-105753787-B Tumor-targeting drug Combretastatin A4 derivatives 南京圣和药业股份有限公司 2018-05-15 CN disclosed
CN-106699771-A Cryptotanshinone compound, as well as preparation method and application thereof 常州大学 2017-05-24 CN disclosed
CN-105753787-A Tumor-targeting-medicine Combretastatin A4 derivatives 南京圣和药业股份有限公司 2016-07-13 CN disclosed
CN-102190625-B Stilbene tumor targeted medicine Combretastatin A4 analogs NANJING SANHOME PHARMACEUTICAL CO LTD 2013-08-28 CN disclosed