Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.94 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.77 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245198 | 0.97 | GRM2 (1.00) | GRM2CYSLTR1CYSLTR2MEN1LMNA | |
| SCHEMBL29466707 | 0.97 | GRM2 (1.00) | GRM2CYSLTR1CYSLTR2MEN1LMNA | |
| SCHEMBL8337653 | 0.96 | GRM2 (1.00) | GRM2CYSLTR1CYSLTR2MEN1LMNA | |
| SCHEMBL9643108 | 0.90 | GRM2 (0.80) | GRM2CYSLTR1CYSLTR2 | |
| SCHEMBL6245754 | 0.86 | CYSLTR1 (0.83) | GRM2CYSLTR1CYSLTR2MEN1LMNA | |
| SCHEMBL8337676 | 0.86 | GRM2 (0.80) | GRM2CYSLTR1CYSLTR2MEN1LMNA | |
| SCHEMBL6243450 | 0.86 | GRM2 (0.80) | GRM2CYSLTR1CYSLTR2MEN1LMNA | |
| SCHEMBL6246394 | 0.85 | GRM2 (1.00) | GRM2CYSLTR1CYSLTR2MEN1LMNA | |
| SCHEMBL6246402 | 0.85 | GRM2 (0.79) | GRM2CYSLTR1CYSLTR2 | |
| SCHEMBL6357175 | 0.85 | GRM2 (1.00) | GRM2CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018386-A2 | ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2004-03-04 | — | — | WO | disclosed |